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MK-677 is generally well-tolerated, but in some cases, it may cause mild water retention, which could temporarily elevate blood pressure

Nat Rev Endocrinol 3 , 157167 (2007)

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While naturally occurring IGF-1 plays a critical role in growth and development, the LR3 modification extends its half-life and dramatically enhances its biological availability making it a favorite for research into athletic performance, muscle rehabilitation, and age-related decline

The most meaningful differences are how each peptide signals the pituitary, how strong the human evidence is for real outcomes, and whether what youre being offered is FDA-approved, compounded, or research-only (Molitch et al., 2011)